{"id":97841,"date":"2026-10-30T15:36:27","date_gmt":"2026-10-30T19:36:27","guid":{"rendered":"https:\/\/noti-america.com\/site\/principal\/?p=97841"},"modified":"2026-10-30T15:36:27","modified_gmt":"2026-10-30T19:36:27","slug":"cientificos-logran-revertir-seis-decadas-de-envejecimiento-celular-en-laboratorio","status":"publish","type":"post","link":"https:\/\/noti-america.com\/site\/principal\/2026\/10\/30\/cientificos-logran-revertir-seis-decadas-de-envejecimiento-celular-en-laboratorio\/","title":{"rendered":"Cient\u00edficos logran revertir seis d\u00e9cadas de envejecimiento celular en laboratorio"},"content":{"rendered":"<p>NOTI-AMERICA.COM | CHILE<\/p>\n<p style=\"text-align: justify\">Investigadores de la Universidad de Bonn, Alemania, lograron transformar c\u00e9lulas sangu\u00edneas de un donante de 80 a\u00f1os en c\u00e9lulas madre neurales con una edad molecular inferior a los 20 a\u00f1os. El hallazgo, publicado en la revista <em>Aging Cell<\/em>, no representa una soluci\u00f3n contra el envejecimiento en humanos, pero ofrece un modelo in\u00e9dito para estudiar c\u00f3mo las c\u00e9lulas recuperan caracter\u00edsticas juveniles.<\/p>\n<p style=\"text-align: justify\">El equipo liderado por el profesor Oliver Br\u00fcstle emple\u00f3 una t\u00e9cnica de reprogramaci\u00f3n directa que omiti\u00f3 convertir primero las c\u00e9lulas en madre pluripotentes. Al transformar los precursores de gl\u00f3bulos rojos de forma directa en c\u00e9lulas madre neurales, los cient\u00edficos pudieron monitorear y evaluar el proceso de rejuvenecimiento gradual a lo largo de m\u00e1s de 100 d\u00edas.<\/p>\n<p style=\"text-align: justify\">El cambio se midi\u00f3 a trav\u00e9s de los relojes epigen\u00e9ticos, marcadores moleculares que estiman la edad biol\u00f3gica seg\u00fan las modificaciones qu\u00edmicas del ADN. Tras la reprogramaci\u00f3n, las c\u00e9lulas mostraron una reducci\u00f3n aproximada de 60 a\u00f1os en su edad molecular en solo 50 d\u00edas. Br\u00fcstle destac\u00f3 que este reinicio paulatino permitir\u00e1 investigar qu\u00e9 factores o sustancias aceleran o frenan la regeneraci\u00f3n.<\/p>\n<p style=\"text-align: justify\">Los resultados cobran especial relevancia para el estudio de enfermedades neurodegenerativas como el Alzheimer, donde la edad biol\u00f3gica es el principal factor de riesgo. Aunque la t\u00e9cnica no constituye un tratamiento cl\u00ednico inmediato, proporciona a la comunidad cient\u00edfica una herramienta fundamental para desentra\u00f1ar los mecanismos biol\u00f3gicos del envejecimiento celular.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NOTI-AMERICA.COM | CHILE Investigadores de la Universidad de Bonn, Alemania, lograron transformar c\u00e9lulas sangu\u00edneas de un donante de 80 a\u00f1os en c\u00e9lulas madre neurales con una edad molecular inferior a los 20 a\u00f1os. El&#46;&#46;&#46;<\/p>\n","protected":false},"author":133,"featured_media":97842,"comment_status":"","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_acf_changed":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"no","rop_publish_now_accounts":{"facebook_10219548024599422_1632221337088128":"","twitter_242054905_242054905":""},"rop_publish_now_history":[{"account":"twitter_242054905_242054905","service":"twitter","timestamp":1793389136,"status":"error"}],"rop_publish_now_status":"done","footnotes":""},"categories":[3709],"tags":[],"class_list":["post-97841","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-bienestar","post_format-post-format-image"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cient\u00edficos logran revertir seis d\u00e9cadas de envejecimiento celular en laboratorio - Noti-America.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/noti-america.com\/site\/principal\/2026\/10\/30\/cientificos-logran-revertir-seis-decadas-de-envejecimiento-celular-en-laboratorio\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos logran revertir seis d\u00e9cadas de envejecimiento celular en laboratorio\" \/>\n<meta property=\"og:description\" content=\"NOTI-AMERICA.COM | CHILE Investigadores de la Universidad de Bonn, Alemania, lograron transformar c\u00e9lulas sangu\u00edneas de un donante de 80 a\u00f1os en c\u00e9lulas madre neurales con una edad molecular inferior a los 20 a\u00f1os. 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