{"id":3220,"date":"2019-01-28T23:32:37","date_gmt":"2019-01-28T23:32:37","guid":{"rendered":"http:\/\/noti-america.com\/site\/ecuador\/?p=3220"},"modified":"2019-01-28T23:33:38","modified_gmt":"2019-01-28T23:33:38","slug":"un-farmaco-biologico-para-tratar-el-cancer-de-retina-en-ninos","status":"publish","type":"post","link":"https:\/\/noti-america.com\/site\/ecuador\/2019\/01\/28\/un-farmaco-biologico-para-tratar-el-cancer-de-retina-en-ninos\/","title":{"rendered":"Un f\u00e1rmaco biol\u00f3gico para tratar el c\u00e1ncer de retina en ni\u00f1os"},"content":{"rendered":"

REDACCI\u00d3N NOTI-AM\u00c9RICA (ECUADOR)<\/p>\n

\n

Cada a\u00f1o se diagnostican alrededor de 8.000 nuevos casos de\u00a0retinoblastoma<\/strong>\u00a0en ni\u00f1os de todo el mundo. Se trata del c\u00e1ncer ocular m\u00e1s frecuente en la poblaci\u00f3n infantil y supone\u00a0el 11% de los tumores malignos diagnosticados en beb\u00e9s<\/strong>\u00a0menores de un a\u00f1o. La mayor\u00eda de los casos son el resultado de la inactivaci\u00f3n\u00a0del gen RB1<\/strong>, que normalmente desempe\u00f1a un papel cr\u00edtico como supresor de tumores.<\/p>\n

\u00abAl administrar el tratamiento a los pacientes, se observ\u00f3 que el virus actuaba con \u00e9xito en las c\u00e9lulas tumorales y no causaba inflamaci\u00f3n\u00bb<\/strong><\/em><\/p>\n

Ahora, un equipo internacional liderado por Guillem Pascual-Pasto, del\u00a0Hospital Sant Joan de Deu de Barcelona<\/strong>, ha desarrollado un tratamiento potencial contra esta enfermedad, llamado\u00a0VCN-01<\/strong>, a partir de\u00a0un virus que infecta y mata las c\u00e9lulas cancerosas<\/strong>\u00a0con un gen RB1 disfuncional.<\/p>\n

Seg\u00fan los resultados del estudio, publicado en la revista\u00a0Science Translational Medicine<\/em>, las\u00a0inyecciones intraoculares del virus<\/strong>\u00a0lograron reducir el crecimiento del tumor y prevenir la met\u00e1stasis\u00a0en ratones.<\/strong>Asimismo, al administrar VCN-01\u00a0a dos pacientes pedi\u00e1tricos<\/strong>, los especialistas observaron que el virus actuaba con \u00e9xito en las c\u00e9lulas tumorales y no causaba inflamaci\u00f3n.<\/p>\n

\u201cEl virus no se replica en tejidos sanos como la retina, lo que hace pensar que ser\u00e1 un tratamiento seguro. Adem\u00e1s, hemos demostrado\u00a0eficacia preliminar en pacientes.<\/strong>\u00a0Ahora nos queda terminar el ensayo cl\u00ednico en personas para obtener conclusiones s\u00f3lidas sobre la seguridad y eficacia del tratamiento\u201d, declara a Sinc Angel M. Carcaboso, investigador del Hospital Sant Joan de Deu y uno de los autores del trabajo.<\/p>\n

\n
\n
\n
\"pascual2HR\"<\/div>\n
\n

Evoluci\u00f3n de los ojos de dos pacientes que recibieron la terapia \/ G. Pascual-Pasto et al., Science Translational Medicine<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

Un tratamiento que ayuda a la quimioterapia<\/strong><\/h2>\n

Actualmente,\u00a0la quimioterapia<\/strong>\u00a0es el principal m\u00e9todo para acabar con este tipo de c\u00e1ncer. No obstante, en los casos en los que el tumor se hace resistente a esta terapia, los especialistas tienen que recurrir a un procedimiento invasivo llamado\u00a0enucleaci\u00f3n<\/strong>\u00a0(extirpaci\u00f3n quir\u00fargica del ojo).<\/p>\n

\n

\u201cNuestro objetivo es tener una opci\u00f3n terap\u00e9utica nueva que\u00a0combinar con la quimioterapia\u201d, afirma Carcaboso<\/strong><\/p>\n<\/div>\n

\u201cA veces la quimioterapia deja de funcionar porque el tumor se hace resistente, por lo que el tratamiento que debe aplicarse consiste en la extirpaci\u00f3n. Si bien cura el c\u00e1ncer, tambi\u00e9n puede suponer la p\u00e9rdida de la vista en los pacientes que adem\u00e1s tengan enfermedad bilateral y un \u00fanico ojo\u201d, precisa Carcaboso.<\/p>\n

\u201cNuestro objetivo final es tener una nueva opci\u00f3n terap\u00e9utica que\u00a0combinar con la quimioterapia<\/strong>\u00a0para evitar la ceguera en pacientes que tienen toda la vida a\u00fan por delante, porque son muy ni\u00f1os\u201d, se\u00f1ala el investigador, que subraya que el VCN-01 es eficaz contra los tumores, independientemente de que estos sean resistentes o no a la quimioterapia.<\/p>\n

Los expertos ahora trabajan para completar la fase I del ensayo cl\u00ednico, en la que probar\u00e1n la estrategia terap\u00e9utica en un m\u00e1ximo de\u00a013 pacientes<\/strong>. Despu\u00e9s, evaluar\u00e1n la seguridad y eficacia para valorar sus futuras aplicaciones.<\/p>\n

\n

Referencia bibliogr\u00e1fica:<\/strong><\/p>\n

Pascual-Pasto, G. et al.\u00a0Therapeutic targeting of the RB1 pathway in retinoblastoma with the oncolytic adenovirus VCN-01.\u00a0Science Translational Medicine<\/a><\/em>. 23 de enero.<\/p>\n<\/div>\n<\/div>\n

Fuente: SINC<\/div>\n","protected":false},"excerpt":{"rendered":"

REDACCI\u00d3N NOTI-AM\u00c9RICA (ECUADOR) Cada a\u00f1o se diagnostican alrededor de 8.000 nuevos casos de\u00a0retinoblastoma\u00a0en ni\u00f1os de todo el mundo. Se trata del c\u00e1ncer ocular m\u00e1s frecuente en la poblaci\u00f3n infantil y supone\u00a0el 11% de los...<\/p>\n","protected":false},"author":17,"featured_media":3221,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"twitter_242054905_242054905":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-3220","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"acf":[],"aioseo_notices":[],"yoast_head":"\nUn f\u00e1rmaco biol\u00f3gico para tratar el c\u00e1ncer de retina en ni\u00f1os - Ecuador | Noti-America.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/noti-america.com\/site\/ecuador\/2019\/01\/28\/un-farmaco-biologico-para-tratar-el-cancer-de-retina-en-ninos\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Un f\u00e1rmaco biol\u00f3gico para tratar el c\u00e1ncer de retina en ni\u00f1os\" \/>\n<meta property=\"og:description\" content=\"REDACCI\u00d3N NOTI-AM\u00c9RICA (ECUADOR) Cada a\u00f1o se diagnostican alrededor de 8.000 nuevos casos de\u00a0retinoblastoma\u00a0en ni\u00f1os de todo el mundo. 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