{"id":1738,"date":"2018-09-07T00:40:55","date_gmt":"2018-09-07T00:40:55","guid":{"rendered":"http:\/\/noti-america.com\/site\/ecuador\/?p=1738"},"modified":"2018-09-07T00:40:55","modified_gmt":"2018-09-07T00:40:55","slug":"un-caballo-de-troya-celular-despierta-el-sistema-inmune-antitumoral","status":"publish","type":"post","link":"https:\/\/noti-america.com\/site\/ecuador\/2018\/09\/07\/un-caballo-de-troya-celular-despierta-el-sistema-inmune-antitumoral\/","title":{"rendered":"Un caballo de Troya celular despierta el sistema inmune antitumoral"},"content":{"rendered":"

REDACCI\u00d3N NOTI-AM\u00c9RICA (ECUADOR)<\/p>\n

Una novedosa terapia, conocida como Celyvir, ha demostrado el efecto antitumoral de virus oncol\u00edticos \u2013capaces de infectar y descomponer las c\u00e9lulas cancerosas\u2013 escondidos en c\u00e9lulas madre mesenquimales, es decir, aquellas que pueden dar lugar a varios tipos de c\u00e9lulas de los tejidos esquel\u00e9ticos, como el cart\u00edlago, el hueso y la grasa.<\/p>\n

La investigaci\u00f3n, realizada en ratones en la Unidad de Biotecnolog\u00eda Celular del Instituto de Salud Carlos III, combina c\u00e9lulas y virus para que act\u00faen como una especie de caballo de Troya celular que despierte al sistema inmunitario antitumoral. El trabajo acaba de ser publicado en la revista\u00a0Cancer Immunology<\/em>.<\/p>\n

\u201cEl estudio ha confirmado en ratones que las c\u00e9lulas madre mesenquimales que transportan al virus antitumoral podr\u00edan obtenerse tanto del propio paciente (c\u00e9lulas sing\u00e9nicas) como de un donante (c\u00e9lulas alog\u00e9nicas), reduciendo en un 35% el volumen del tumor\u201d, explica \u00c1lvaro Morales, autor principal del estudio.<\/p>\n

En ambos casos, el tratamiento no solo consigui\u00f3 activar la respuesta inmune, sino que aument\u00f3 la infiltraci\u00f3n de ciertas c\u00e9lulas inmunitarias anticancer\u00edgenas (los llamados neutr\u00f3filos N2 antitumorales) en los c\u00e1nceres tratados. Trabajos anteriores han se\u00f1alado que esta mayor infiltraci\u00f3n del sistema inmunitario en el tumor est\u00e1 extensamente relacionada con un mejor pron\u00f3stico de la enfermedad y una mayor respuesta a otras inmunoterapias.<\/p>\n

Obtener un tratamiento universal<\/strong><\/p>\n

Los virus oncol\u00edticos son aquellos que se replican selectivamente en c\u00e9lulas tumorales, destruy\u00e9ndolas. El problema de esta terapia es que el virus no llega al tumor por s\u00ed solo, puesto que el sistema inmunitario suele ejercer una respuesta antiviral contra \u00e9l.<\/p>\n

Para solucionarlo, los expertos han utilizado c\u00e9lulas madre mesenquimales, transportando esos virus en su interior como si de un caballo de Troya celular se tratase. De este modo, el virus oncol\u00edtico llega al tumor dentro de las propias c\u00e9lulas madre, donde se libera y produce una mayor respuesta antitumoral.<\/p>\n

\u201cLos resultados abren la posibilidad de producir un tratamiento universal de c\u00e9lulas madre mesenquimales como transportadoras del virus oncol\u00edtico sin necesidad de obtenerlas de los pacientes, lo que facilita la rapidez y disponibilidad de esta viroinmunoterapia\u201d, concluye Morales.<\/p>\n

[youtube https:\/\/www.youtube.com\/watch?v=AIKMYkXJva0]<\/p>\n

\n

Fuente: ISCIII<\/p>\n

Referencia bibliogr\u00e1fica:<\/strong><\/p>\n

Morales-Molina \u00c1, Gambera S, Cejalvo T, Moreno R, Rodr\u00edguez-Milla M\u00c1, Peris\u00e9-Barrios AJ, Garc\u00eda-Castro J. \u2018Antitumor virotherapy using syngeneic or allogeneic mesenchymal stem cell carriers induces systemic immune response and intratumoral leukocyte infiltration in mice\u2019.\u00a0Cancer Immunol Immunother<\/em>. 2018 Jul 31. doi: 10.1007\/s00262-018-2220-2.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

REDACCI\u00d3N NOTI-AM\u00c9RICA (ECUADOR) Una novedosa terapia, conocida como Celyvir, ha demostrado el efecto antitumoral de virus oncol\u00edticos \u2013capaces de infectar y descomponer las c\u00e9lulas cancerosas\u2013 escondidos en c\u00e9lulas madre mesenquimales, es decir, aquellas que...<\/p>\n","protected":false},"author":17,"featured_media":1739,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"twitter_242054905_242054905":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[35],"tags":[],"class_list":["post-1738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"acf":[],"aioseo_notices":[],"yoast_head":"\nUn caballo de Troya celular despierta el sistema inmune antitumoral - 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