{"id":16262,"date":"2026-03-17T12:19:55","date_gmt":"2026-03-17T15:19:55","guid":{"rendered":"https:\/\/noti-america.com\/site\/argentina\/?p=16262"},"modified":"2026-03-17T12:19:55","modified_gmt":"2026-03-17T15:19:55","slug":"cientificos-de-harvard-y-cold-spring-harbor-revelan-el-secreto-del-desarrollo-cerebral","status":"publish","type":"post","link":"https:\/\/noti-america.com\/site\/argentina\/2026\/03\/17\/cientificos-de-harvard-y-cold-spring-harbor-revelan-el-secreto-del-desarrollo-cerebral\/","title":{"rendered":"Cient\u00edficos de Harvard y Cold Spring Harbor revelan el secreto del desarrollo cerebral"},"content":{"rendered":"<p>NOTI-AMERICA.COM | ARGENTINA<\/p>\n<p style=\"text-align: justify\">El cerebro humano inicia su formaci\u00f3n como una sola c\u00e9lula. Cuando el proceso concluye, alberga una red de 170 mil millones de c\u00e9lulas. La pregunta que surge es c\u00f3mo se organiza a trav\u00e9s de ese desarrollo.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Investigadores del Laboratorio Cold Spring Harbor con la colaboraci\u00f3n de la Universidad de Harvard y de la universidad ETH Z\u00fcrich de Suiza plantearon una nueva explicaci\u00f3n para el desarrollo del cerebro.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Publicaron los resultados en la revista cient\u00edfica Neuron, publicada por la editorial Elsevier. La sencillez de la respuesta podr\u00eda influir en el estudio de la biolog\u00eda y la inteligencia artificial.<\/p>\n<p><strong>C\u00f3mo cada c\u00e9lula interpreta su posici\u00f3n<\/strong><\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Stan Kerstjens, postdoc en el laboratorio del profesor Anthony Zador en Cold Spring Harbor, plante\u00f3 la pregunta en t\u00e9rminos de informaci\u00f3n posicional.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Seg\u00fan explic\u00f3, \u201clo \u00fanico que una c\u00e9lula \u2018ve\u2019 es a s\u00ed misma y a sus vecinas. Pero su destino depende de su ubicaci\u00f3n. Una c\u00e9lula en el lugar equivocado se convierte en algo err\u00f3neo, y el cerebro no se desarrolla de forma adecuada. Entonces, cada c\u00e9lula debe resolver dos cuestiones: \u00bfD\u00f3nde estoy? \u00bfEn qu\u00e9 debo convertirme?\u201d<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">En la investigaci\u00f3n publicada en Neuron, Kerstjens, Zador y sus colegas postularon una nueva teor\u00eda sobre c\u00f3mo el cerebro se organiza durante el desarrollo.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Durante mucho tiempo, se consider\u00f3 que las c\u00e9lulas intercambiaban informaci\u00f3n posicional principalmente a trav\u00e9s de se\u00f1ales qu\u00edmicas.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Esto resulta eficaz para pocas c\u00e9lulas, se\u00f1ala Kerstjens, pero el cerebro est\u00e1 compuesto por miles de millones, cada una con la necesidad de ubicarse correctamente.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Las se\u00f1ales qu\u00edmicas solo alcanzan cierto rango antes de disiparse. Surge entonces la pregunta: \u00bfc\u00f3mo logran las c\u00e9lulas, ubicadas en zonas profundas de un cerebro en crecimiento, \u201csaber\u201d su posici\u00f3n?<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Kerstjens ofreci\u00f3 una comparaci\u00f3n familiar: \u201cConsideremos c\u00f3mo las poblaciones humanas se expanden por un pa\u00eds a lo largo de generaciones. Los descendientes se asientan cerca de sus padres, as\u00ed que quienes comparten ascendencia terminan en regiones vecinas, al formar estructuras geogr\u00e1ficas extensas sin necesitar comunicaci\u00f3n a larga distancia\u201d.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Aclar\u00f3: \u201cSostenemos que un principio similar opera en el cerebro en desarrollo. Las c\u00e9lulas que descienden de un mismo progenitor tienden a mantenerse pr\u00f3ximas entre s\u00ed\u201d.<\/p>\n<p><strong>La propuesta del modelo<\/strong><\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">El modelo basado en linaje sostiene que\u00a0<strong>las c\u00e9lulas se posicionan siguiendo la proximidad a sus progenitores, formando agrupaciones sin depender \u00fanicamente de se\u00f1ales qu\u00edmicas<\/strong>. Esta perspectiva introduce un mecanismo adicional que explica c\u00f3mo grandes cantidades de c\u00e9lulas logran ubicarse correctamente durante el desarrollo cerebral.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Para probar esta teor\u00eda, Kerstjens y sus colegas crearon lo que denominan un modelo basado en linaje de informaci\u00f3n posicional escalable.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Comenzaron con c\u00e1lculos te\u00f3ricos y luego evaluaron su hip\u00f3tesis a gran escala. Analizaron la expresi\u00f3n g\u00e9nica individual y grupal en cerebros de ratones en etapas de desarrollo. Finalmente, comprobaron los resultados en peces cebra, al demostrar que el modelo es aplicable en cerebros de diferentes tama\u00f1os.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Adem\u00e1s, expusieron que comprender c\u00f3mo una sola c\u00e9lula puede dar lugar a la complejidad del cerebro ayuda para abordar interrogantes fundamentales sobre la inteligencia y el funcionamiento mental.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Sostuvieron que ese conocimiento no solo es \u00fatil para la neurobiolog\u00eda, sino que tambi\u00e9n puede influir en el desarrollo de modelos de inteligencia artificial autorreplicantes.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Kerstjens afirm\u00f3 que el modelo respalda la idea de que las se\u00f1ales qu\u00edmicas funcionan en conjunto con un mecanismo basado en linaje para transmitir informaci\u00f3n posicional.<\/p>\n<p><strong>Implicancias y alcance de la hip\u00f3tesis<\/strong><\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Si bien el trabajo de Kerstjens se centra en el cerebro, la teor\u00eda podr\u00eda aplicarse a otros tipos de tejidos en desarrollo, incluidas las neoplasias.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">Incluso puede haber repercusiones para los modelos de inteligencia artificial autorreplicantes que transmiten informaci\u00f3n entre generaciones, de modo an\u00e1logo a las c\u00e9lulas cerebrales humanas.<\/p>\n<p style=\"text-align: justify\" data-mrf-recirculation=\"Links inline\">\u201cEl cerebro de alguna manera nos hace inteligentes\u201d, sostuvo Kerstjens. \u201c\u00bfC\u00f3mo logr\u00f3 acumular esta capacidad, no solo durante su desarrollo, sino tambi\u00e9n a lo largo de la evoluci\u00f3n? Esto representa una pieza dentro de ese gran rompecabezas\u201d, a\u00f1adi\u00f3.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NOTI-AMERICA.COM | ARGENTINA El cerebro humano inicia su formaci\u00f3n como una sola c\u00e9lula. Cuando el proceso concluye, alberga una red de 170 mil millones de c\u00e9lulas. La pregunta que surge es c\u00f3mo se organiza&#46;&#46;&#46;<\/p>\n","protected":false},"author":133,"featured_media":16263,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"twitter_242054905_242054905":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"categories":[425],"tags":[],"class_list":["post-16262","post","type-post","status-publish","format-image","has-post-thumbnail","hentry","category-bienestar","post_format-post-format-image"],"acf":[],"aioseo_notices":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.9 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Cient\u00edficos de Harvard y Cold Spring Harbor revelan el secreto del desarrollo cerebral - Argentina | Noti-America.com<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/noti-america.com\/site\/argentina\/2026\/03\/17\/cientificos-de-harvard-y-cold-spring-harbor-revelan-el-secreto-del-desarrollo-cerebral\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cient\u00edficos de Harvard y Cold Spring Harbor revelan el secreto del desarrollo cerebral\" \/>\n<meta property=\"og:description\" content=\"NOTI-AMERICA.COM | ARGENTINA El cerebro humano inicia su formaci\u00f3n como una sola c\u00e9lula. 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